Fibroblast Growth Factor 19 Serum Levels: Relation to Renal Function and Metabolic Parameters - Research portal of Justus Liebig University Giessen:

Journal article

Fibroblast Growth Factor 19 Serum Levels: Relation to Renal Function and Metabolic Parameters

Authors list: Reiche, M; Bachmann, A; Lössner, U; Blüher, M; Stumvoll, M; Fasshauer, M

Publication year: 2010

Pages: 178-181

Journal: Hormone and Metabolic Research

Volume number: 42

Issue number: 3

ISSN: 0018-5043

DOI Link: https://doi.org/10.1055/s-0029-1243249

Publisher: Thieme Publishing / Georg Thieme Verlag

Abstract:
Fibroblast growth factor 19 (FGF19) was recently introduced as a novel metabolic regulator reversing diabetes mellitus, hepatic steatosis, hyperlipidemia, and adiposity. In the current study, we determined circulating FGF19 levels in patients on chronic hemodialysis (CD) as compared to controls with a glomerular filtration rate (GFR) above 50 ml/min. FGF19 was measured by ELISA in control (n = 60) and CD (n = 60) patients and correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation, in both groups. Median serum FGF19 levels were 1.5-fold higher in CD patients (266.7 mu g/l) as compared to subjects with a GFR above 50 ml/min (178.1 mu g/l) (p = 0.001). Furthermore, fasting glucose negatively and independently predicted circulating FGF19 in controls (p < 0.05). Moreover, adiponectin was a positive and C-reactive protein was a negative independent predictor of FGF19 serum concentrations in CD patients. Taken together, we have demonstrated that circulating FGF19 levels are significantly increased in end-stage renal disease. Furthermore, FGF19 is associated with a beneficial metabolic profile in both control and CD patients.

Authors/Editors

- Uni.-Prof. Dr. Mathias Faßhauer

Citation Styles

Harvard Citation style: Reiche, M., Bachmann, A., Lössner, U., Blüher, M., Stumvoll, M. and Fasshauer, M. (2010) Fibroblast Growth Factor 19 Serum Levels: Relation to Renal Function and Metabolic Parameters, Hormone and Metabolic Research, 42(3), pp. 178-181. https://doi.org/10.1055/s-0029-1243249

APA Citation style: Reiche, M., Bachmann, A., Lössner, U., Blüher, M., Stumvoll, M., & Fasshauer, M. (2010). Fibroblast Growth Factor 19 Serum Levels: Relation to Renal Function and Metabolic Parameters. Hormone and Metabolic Research. 42(3), 178-181. https://doi.org/10.1055/s-0029-1243249