Journalartikel

Jahr der Veröffentlichung: 2010

Seiten: 171-173

Zeitschrift: Diabetes Care

Bandnummer: 33

Heftnummer: 1

ISSN: 0149-5992

DOI Link: https://doi.org/10.2337/dc09-1351

Verlag: American Diabetes Association

Abstract: 
OBJECTIVE - To investigate serum levels of the adipokine chemerin in patients on chronic hemodialysis (CD) as compared with control patients with a glomerular filtration rate (GFR) >50 ml/min.RESEARCH DESIGN AND METHODS - Chemerin was quantified by ELISA in control patients (n = 60) and CD patients (n = 60) and correlated with clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation, in both groups.RESULTS - Median serum chemerin levels were more than twofold higher in CD patients (542.2 mu g/l) compared with subjects with a GFR >50 ml/min (254.3 mu g/l) (P < 0.001). Furthermore, GFR, as assessed by the original Modification of Diet in Renal Disease formula, independently predicted circulating chemerin concentrations in Multiple regression analyses in both control patients (P < 0.05) and CD patients (P < 0.01).CONCLUSIONS - We demonstrate that markers of renal function are independently related to circulating chemerin levels.

Harvard-Zitierstil: Pfau, D., Bachmann, A., Lössner, U., Kratzsch, J., Blüher, M., Stumvoll, M., et al. (2010) Serum Levels of the Adipokine Chemerin in Relation to Renal Function, Diabetes Care, 33(1), pp. 171-173. https://doi.org/10.2337/dc09-1351

APA-Zitierstil: Pfau, D., Bachmann, A., Lössner, U., Kratzsch, J., Blüher, M., Stumvoll, M., & Fasshauer, M. (2010). Serum Levels of the Adipokine Chemerin in Relation to Renal Function. Diabetes Care. 33(1), 171-173. https://doi.org/10.2337/dc09-1351