Journalartikel

Jahr der Veröffentlichung: 2011

Seiten: 117-120

Zeitschrift: Hormone and Metabolic Research

Bandnummer: 43

Heftnummer: 2

ISSN: 0018-5043

DOI Link: https://doi.org/10.1055/s-0030-1267917

Verlag: Thieme Publishing / Georg Thieme Verlag

Abstract: 
Fasting-induced adipose factor/angiopoietin-like protein 4 (FIAF/Angptl4) was recently introduced as a novel adipokine influencing glucose and lipid homeostasis. In the current study, we quantified circulating FIAF/Angtl4 levels in patients on chronic hemodialysis (CD) as compared to controls with a glomerular filtration rate above 50 ml/min. FIAF/Angptl4 was determined by ELISA in control (n = 60) and CD (n = 60) patients and correlated to clinical and biochemical measures of renal function, glucose and lipid metabolism, as well as inflammation, in both groups. Median serum FIAF/Angptl4 levels were more than 5-fold higher in CD patients (48.3 mu g/l) as compared to control subjects (8.4 mu g/l) (p < 0.001). Furthermore, serum creatinine independently predicted FIAF/Angptl4 concentrations in multiple regression analyses in control subjects (p < 0.01). In CD patients, C-reactive protein was independently and positively associated with circulating FIAF/Angptl4 (p < 0.01). Taken together, we show that serum FIAF/Angptl4 levels are significantly increased in end-stage renal disease and independently associated with markers of renal function in control subjects.

Harvard-Zitierstil: Baranowski, T., Kralisch, S., Bachmann, A., Lössner, U., Kratzsch, J., Blüher, M., et al. (2011) Serum Levels of the Adipokine Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Depend on Renal Function, Hormone and Metabolic Research, 43(2), pp. 117-120. https://doi.org/10.1055/s-0030-1267917

APA-Zitierstil: Baranowski, T., Kralisch, S., Bachmann, A., Lössner, U., Kratzsch, J., Blüher, M., Stumvoll, M., & Fasshauer, M. (2011). Serum Levels of the Adipokine Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Depend on Renal Function. Hormone and Metabolic Research. 43(2), 117-120. https://doi.org/10.1055/s-0030-1267917