Journal article

Publication year: 2010

Pages: 629-632

Journal: Journal of Endocrinological Investigation

Volume number: 33

Issue number: 9

ISSN: 0391-4097

DOI Link: https://doi.org/10.1007/BF03346661

Publisher: Springer

Abstract: 
Background Preeclampsia (PE) is a serious corn plication in pregnancy which increases the future risk for vascular and metabolic disease in both mother and newborn Recently, lipocalin 2 has been introduced as a novel adipokine which contributes to obesity insulin resistance and vascular disease Arm In the current study, we investigated lipocalin 2 serum levels in PE patients as compared to healthy gestational age matched controls Subjects and methods Lipocalin 2 serum concentrations were quantified by enzyme linked immunosorbent assay in control (no =22) and PE (no =22) patients Furthermore, lipocalin 2 levels were correlated to clinical and biochemical measures of renal function glucose and lipid metabolism as well as in flammation Results Median maternal lipocalin 2 concentrations were significantly increased in PE (121 3 mu g/l) as compared to control subjects (99 8 mu g/l) (p < 0 05) Further more circulating lipocalin 2 correlated positively with diastolic blood pressure creatinine and C reactive protein In multivariate analyses, creatinine and C reactive protein remained independently associated with lipocalin 2 levels Conclusions We demonstrate that maternal lipocalin 2 con centrations are significantly increased in PE Furthermore markers of renal function and inflammation independently predict circulating lipocalin 2 (J Endocrinol Invest 33 629 632, 2010) (c) 2010 Editrice Kurtis

Harvard Citation style: Stepan, H., Philipp, A., Reiche, M., Klostermann, K., Schrey, S., Reisenbüchler, C., et al. (2010) Serum levels of the adipokine lipocalin-2 are increased in preeclampsia, Journal of Endocrinological Investigation, 33(9), pp. 629-632. https://doi.org/10.1007/BF03346661

APA Citation style: Stepan, H., Philipp, A., Reiche, M., Klostermann, K., Schrey, S., Reisenbüchler, C., Lössner, U., Kratzsch, J., Blüher, M., Stumvoll, M., & Fasshauer, M. (2010). Serum levels of the adipokine lipocalin-2 are increased in preeclampsia. Journal of Endocrinological Investigation. 33(9), 629-632. https://doi.org/10.1007/BF03346661