Journal article

Publication year: 2011

Pages: 669-672

Journal: Metabolism

Volume number: 60

Issue number: 5

ISSN: 0026-0495

DOI Link: https://doi.org/10.1016/j.metabol.2010.06.019

Publisher: Elsevier

Abstract: 
Zinc-alpha 2-glycoprotein (ZAG) has recently been proposed as a new adipokine involved in body weight control. In the current study, we investigated renal elimination of this adipokine by comparing circulating ZAG levels in patients on chronic hemodialysis (CD) with controls. Sixty CD patients and 60 controls with a glomerular filtration rate greater than 50 mL/min were included. Serum concentrations of ZAG were determined by enzyme-linked immunosorbent assay; and its relationship with renal function, glucose and lipid metabolism, as well as inflammation was studied in both groups. Median ZAG serum levels were almost 2-fold higher in CD patients (94.4 +/- 29.4 mg/L) as compared with controls (48.3 +/- 23.5 mg/L) (P < .001). Furthermore, circulating ZAG was negatively correlated with fasting insulin, homeostasis model assessment of insulin resistance, and leptin in controls in univariate analysis. Moreover, CD independently predicted ZAG concentrations in multiple regression analysis. Renal filtration appears to be an important route of ZAG elimination, and markers of renal function should be included in studies on ZAG physiology. (C) 2011 Elsevier Inc. All rights reserved.

Harvard Citation style: Philipp, A., Kralisch, S., Bachmann, A., Lössner, U., Kratzsch, J., Blüher, M., et al. (2011) Serum levels of the adipokine zinc-alpha 2-glycoprotein are increased in chronic hemodialysis, Metabolism, 60(5), pp. 669-672. https://doi.org/10.1016/j.metabol.2010.06.019

APA Citation style: Philipp, A., Kralisch, S., Bachmann, A., Lössner, U., Kratzsch, J., Blüher, M., Stumvoll, M., & Fasshauer, M. (2011). Serum levels of the adipokine zinc-alpha 2-glycoprotein are increased in chronic hemodialysis. Metabolism. 60(5), 669-672. https://doi.org/10.1016/j.metabol.2010.06.019