Journalartikel

Jahr der Veröffentlichung: 2007

Seiten: 2588-2592

Zeitschrift: Diabetes Care

Bandnummer: 30

Heftnummer: 10

ISSN: 0149-5992

DOI Link: https://doi.org/10.2337/dc07-0275

Verlag: American Diabetes Association

Abstract: 
OBJECTIVE - Retinol-binding protein (RBP)-4 was recently identified as an adipokine that induces insulin resistance. In the current study, we investigated RBP-4 serum levels in diabetic and nondiabetic patients on chronic hemodialysis (CD) compared with control subjects with a glomerular filtration rate > 50 ml/min. The majority of the diabetic subjects used oral hypoglycemic agents or insulin.RESEARCH DESIGN AND METHODS - RBP-4 was determined by enzyme-linked immunosorbent assay in control subjects (n = 59) and CD patients (n = 58) and correlated with clinical and biochemical measures of renal function, glucose and lipid metabolism, and inflammation in both groups.RESULTS - Mean serum RBP-4 levels were almost fourfold higher in CD patients (102 30 mg/l) compared with control subjects (28 +/- 8 mg/l). Furthermore, serum creatinine independently predicted RBP-4 concentrations in multiple regression analyses in both control subjects and CD patients. In addition, C-reactive protein and systolic blood pressure independently and negatively correlated with RBP-4 serum concentrations in CD patients but not control subjects. In contrast, markers of glucose and lipid metabolism were not independently related to serum RBP-4 in control subjects or CD patients.CONCLUSIONS - We show that markers of renal function are independently related to serum RBP-4 levels.

Harvard-Zitierstil: Ziegelmeier, M., Bachmann, A., Seeger, J., Lössner, U., Kratzsch, J., Blüher, M., et al. (2007) Serum levels of adipokine retinol-binding protein-4 in relation to renal function, Diabetes Care, 30(10), pp. 2588-2592. https://doi.org/10.2337/dc07-0275

APA-Zitierstil: Ziegelmeier, M., Bachmann, A., Seeger, J., Lössner, U., Kratzsch, J., Blüher, M., Stumvoll, M., & Fasshauer, M. (2007). Serum levels of adipokine retinol-binding protein-4 in relation to renal function. Diabetes Care. 30(10), 2588-2592. https://doi.org/10.2337/dc07-0275