Journal article

Publication year: 2008

Pages: 2241-2247

Journal: Journal of Cellular Biochemistry

Volume number: 104

Issue number: 6

ISSN: 0730-2312

DOI Link: https://doi.org/10.1002/jcb.21782

Publisher: Wiley

Abstract: 
Serum amyloid A (SAA) 3 has been characterized as an inflammatory adipocyte-secreted acute-phase reactant. In the current study, regulation of SAA3 by the proinflammatory and insulin resistance-inducing cytokine interleukin(IL)-1 beta was determined in 3T3-L1 and brown adipocytes. Interestingly, SAA3 mRNA and protein synthesis were dramatically increased by IL-1 beta in a time-dependent fashion with maximal induction after 24 h. Furthermore, IL-1 beta significantly induced SAA3 mRNA expression dose-dependently with maximal 36.4-fold upregulation seen at 2 ng/ml effector. Moreover, IL-1 beta-induced SAA3 expression was mediated by nuclear factor-kappa B and janus kinase 2. Taken together, our data show a potent upregulation of SAA3 by IL-1 beta.

Harvard Citation style: Sommer, G., Weise, S., Kralisch, S., Scherer, P., Lössner, U., Blüher, M., et al. (2008) The adipokine SAA3 is induced by interleukin-1 beta in mouse adipocytes, Journal of Cellular Biochemistry, 104(6), pp. 2241-2247. https://doi.org/10.1002/jcb.21782

APA Citation style: Sommer, G., Weise, S., Kralisch, S., Scherer, P., Lössner, U., Blüher, M., Stumvoll, M., & Fasshauer, M. (2008). The adipokine SAA3 is induced by interleukin-1 beta in mouse adipocytes. Journal of Cellular Biochemistry. 104(6), 2241-2247. https://doi.org/10.1002/jcb.21782