Journal article

Publication year: 2007

Pages: 257-261

Journal: European journal of endocrinology

Volume number: 156

Issue number: 2

ISSN: 0804-4643

DOI Link: https://doi.org/10.1530/eje.1.02328

Publisher: Oxford University Press

Abstract: 
Objective: Tissue inhibitor of metalloproteinase (TIMP)-1. is upregulated in fat of obese rodents and promotes adipose tissue development in these animals. However, it is unclear whether TIMP-1 independently predicts adiposity in humans and whether serum levels are increased in s.c. and visceral obesity.Design: Twenty-four lean, 16 s.c. obese, and 20 visceral obese subjects were studied.Methods: Plasma TIMP-1 concentrations were quantified using ELISAs and correlated to clinical parameters.Results: Plasma TIMP-1 levels were significantly different between lean (156 +/- 42 mu g/l), s.c. obese (186 +/- 52 mu g/l), and visceral obese (198 +/- 42 mu g/l) subjects (P < 0.01). Furthermore, TIMP-1 correlated positively with body mass index (BMI), waist-to-hip ratio (WHR), % body fat, fasting insulin, free fatty acids, cholesterol, leptin, interleukin-6, and negatively with adiponectin (P < 0.05). Moreover, TIMP-1 serum levels predicted % body fat but not WHR independent of age, sex, and plasma insulin.Conclusions: We demonstrate that increased TIMP-1 serum levels are found with increased adiposity in humans.

Harvard Citation style: Kralisch, S., Blüher, M., Tönjes, A., Lössner, U., Paschke, R., Stumvoll, M., et al. (2007) Tissue inhibitor of metalloproteinase-1 predicts adiposity in humans, European journal of endocrinology, 156(2), pp. 257-261. https://doi.org/10.1530/eje.1.02328

APA Citation style: Kralisch, S., Blüher, M., Tönjes, A., Lössner, U., Paschke, R., Stumvoll, M., & Fasshauer, M. (2007). Tissue inhibitor of metalloproteinase-1 predicts adiposity in humans. European journal of endocrinology. 156(2), 257-261. https://doi.org/10.1530/eje.1.02328