Journal article

Publication year: 2009

Pages: 1196-1200

Journal: FEBS Letters

Volume number: 583

Issue number: 7

ISSN: 1873-3468

DOI Link: https://doi.org/10.1016/j.febslet.2009.03.015

Publisher: Wiley

Abstract: 
The impact of interleukin (IL)-1 beta on tumor necrosis factor alpha-induced adipose-related protein (TIARP)/six-transmembrane protein of prostate 2 (STAMP2) was determined in adipocytes. TIARP/STAMP2 mRNA synthesis was significantly stimulated by IL-1 beta in a dose- and time-dependent fashion in 3T3-L1 adipocytes. Signaling studies suggested that janus kinase 2, nuclear factor kappa B, and p44/42 mitogen-activated protein kinase are involved in IL-1 beta-induced TIARP/STAMP2 mRNA expression. Furthermore, IL-1 beta, TNF alpha, and IL-6 showed synergistic stimulatory effects on TIARP/STAMP2 gene expression. Moreover, both TIARP/STAMP2 mRNA synthesis and protein expression were induced by IL-1 beta in fully differentiated human mesenchymal stem cell-derived adipocytes (hMSC-Ad). Taken together, TIARP/STAMP2 is highly upregulated in 3T3-L1 cells and hMSC-Ad by IL-1 beta and might, therefore, modulate proinflammatory and insulin resistance-inducing effects of IL-1 beta. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

Harvard Citation style: Kralisch, S., Sommer, G., Weise, S., Lipfert, J., Lössner, U., Kamprad, M., et al. (2009) Interleukin-1 beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro, FEBS Letters, 583(7), pp. 1196-1200. https://doi.org/10.1016/j.febslet.2009.03.015

APA Citation style: Kralisch, S., Sommer, G., Weise, S., Lipfert, J., Lössner, U., Kamprad, M., Schröck, K., Blüher, M., Stumvoll, M., & Fasshauer, M. (2009). Interleukin-1 beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro. FEBS Letters. 583(7), 1196-1200. https://doi.org/10.1016/j.febslet.2009.03.015