Journal article

Publication year: 2009

Pages: 103-108

Journal: Journal of Cellular Biochemistry

Volume number: 106

Issue number: 1

ISSN: 0730-2312

DOI Link: https://doi.org/10.1002/jcb.21980

Publisher: Wiley

Abstract: 
Lipocalin-2 (Lcn2) has recently been isolated as an adipocyte-secreted acute phase reactant that plays a role in insulin resistance, obesity, and atherosclerotic disease.]it the current study, we determined regulation of Lcn2 by the proinflammatory and insulin resistance-inducing cytokine interleukin (IL)-1 beta in 3T3-L1 and brown adipocytes by relative real-time reverse transcription-polymerase chain reaction. Interestingly, IL-1 beta dramatically induced Lcn2 mRNA in both adipocyte models. Furthermore, Lcn2 protein secretion was dramatically upregulated in 3T3-L1 adipocytes after 24 h of IL-1 beta treatment. Experiments using pharmacological inhibitors indicated that IL-1 beta-induced Lcn2 expression is mediated via nuclear factor kappa B and janus kinase 2. Taken together, our results show an upregulation of Lcn2 by IL-1 beta in fat cells implicating a potential role of this adipocyte-secreted acute phase reactant in the development of insulin resistance, obesity, and associated disorders including cardiovascular disease. J. Cell. Biochern. 106: 103-108, 2009. (C) 2008 Wiley-Liss, Inc.

Harvard Citation style: Sommer, G., Weise, S., Kralisch, S., Lössner, U., Blüher, M., Stumvoll, M., et al. (2009) Lipocalin-2 Is Induced by Interleukin-1 beta in Murine Adipocytes In Vitro, Journal of Cellular Biochemistry, 106(1), pp. 103-108. https://doi.org/10.1002/jcb.21980

APA Citation style: Sommer, G., Weise, S., Kralisch, S., Lössner, U., Blüher, M., Stumvoll, M., & Fasshauer, M. (2009). Lipocalin-2 Is Induced by Interleukin-1 beta in Murine Adipocytes In Vitro. Journal of Cellular Biochemistry. 106(1), 103-108. https://doi.org/10.1002/jcb.21980