Journal article

Publication year: 2009

Pages: 314-318

Journal: American Journal of Hypertension

Volume number: 22

Issue number: 3

ISSN: 0895-7061

DOI Link: https://doi.org/10.1038/ajh.2008.340

Publisher: Oxford University Press

Abstract: 
BACKGROUNDPreeclampsia is a serious complication in pregnancy with an increased future cardiovascular and metabolic risk for both mother and newborn. Recently, angiopoietin-related growth factor (AGF) was introduced as a novel liver-derived protein with proangiogenic and insulin-sensitizing effects. In the current study, we hypothesized that serum levels of AGF would be lower in preeclamptic patients as compared to healthy controls.METHODSAGF was quantified by enzyme-linked immunosorbent assay (ELISA) in control and preeclamptic patients during pregnancy (Control: n =22, Preeclampsia: n =22) and 6 months after delivery (Control: n = 20, Preeclampsia: n =20). Furthermore, circulating AGF was correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation.RESULTSDuring pregnancy, median maternal AGF concentrations were significantly higher in preeclampsia (191.6 mu g/l) as compared to control subjects (136.3 mu g/l) (P = 0.004). Furthermore, preeclampsia and systolic blood pressure (SBP) were associated with AGF levels in multivariate analyses independent of maternal age. However, higher circulating AGF concentrations in preeclampsia did not persist 6 months after delivery.CONCLUSIONSMaternal AGF serum levels are significantly and paradoxically higher in preeclampsia during pregnancy. However, median postpartum circulating AGF levels are similar in preeclampsia and normal pregnancies.

Harvard Citation style: Stepan, H., Ebert, T., Schrey, S., Reisenbüchler, C., Stein, S., Lössner, U., et al. (2009) Serum Levels of Angiopoietin-Related Growth Factor Are Increased in Preeclampsia, American Journal of Hypertension, 22(3), pp. 314-318. https://doi.org/10.1038/ajh.2008.340

APA Citation style: Stepan, H., Ebert, T., Schrey, S., Reisenbüchler, C., Stein, S., Lössner, U., Blüher, M., Stumvoll, M., Kratzsch, J., Faber, R., & Fasshauer, M. (2009). Serum Levels of Angiopoietin-Related Growth Factor Are Increased in Preeclampsia. American Journal of Hypertension. 22(3), 314-318. https://doi.org/10.1038/ajh.2008.340