Journal article

Publication year: 2006

Pages: 26-32

Journal: Trends in Endocrinology & Metabolism

Volume number: 17

Issue number: 1

ISSN: 1043-2760

DOI Link: https://doi.org/10.1016/j.tem.2005.11.008

Publisher: Cell Press

Abstract: 
The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome and related cardiovascular disorders. Three main functions of adipocytes have been proposed to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), energy dissipation/thermogenesis, and energy storage. There is mounting evidence that this repertoire of actions and reactions contributes to whole-body glucose and energy homeostasis, the control of blood pressure, immune-system function, haemostasis and atherosclerosis. In this article we highlight the most recent examples of adipocyte-based therapies and discuss future pharmacological options for exploiting this triad of adipocyte functions.

Harvard Citation style: Klein, J., Perwitz, N., Kraus, D. and Fasshauer, M. (2006) Adipose tissue as source and target for novel therapies, Trends in Endocrinology & Metabolism, 17(1), pp. 26-32. https://doi.org/10.1016/j.tem.2005.11.008

APA Citation style: Klein, J., Perwitz, N., Kraus, D., & Fasshauer, M. (2006). Adipose tissue as source and target for novel therapies. Trends in Endocrinology & Metabolism. 17(1), 26-32. https://doi.org/10.1016/j.tem.2005.11.008