Journal article

Publication year: 2005

Pages: 455-459

Journal: Hormone and Metabolic Research

Volume number: 37

Issue number: 7

ISSN: 0018-5043

DOI Link: https://doi.org/10.1055/s-2005-870240

Publisher: Thieme Publishing / Georg Thieme Verlag

Abstract: 
Aldosterone is a mineralocorticoid hormone that regulates blood pressure and salt/water balance. Increased aldosterone levels are found in states of disturbed energy balance such as the metabolic syndrome. Adipose tissue has been recognized to play a pivotal role in the regulation of energy homeostasis. We investigated direct aldosterone effects on brown adipocyte function. Aldosterone dose-dependently inhibited expression of uncoupling protein-1 (UCP-1) by 30% (p < 0.01). Furthermore, aldosterone dose-dependently impaired insulin-induced glucose uptake by about 25% (p < 0.01). On a transcriptional level, mRNA of the proinflammatory adipokines leptin and monocyte chemoattractant protem-1 (MCP-1) was increased by 5,000% and 40%, respectively, by aldosterone exposure (p < 0.05). This study demonstrates that aldosterone directly impacts on major adipose functions including stimulation of proinflammatory adipokines.

Harvard Citation style: Kraus, D., Jäger, J., Meier, B., Fasshauer, M. and Klein, J. (2005) Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes, Hormone and Metabolic Research, 37(7), pp. 455-459. https://doi.org/10.1055/s-2005-870240

APA Citation style: Kraus, D., Jäger, J., Meier, B., Fasshauer, M., & Klein, J. (2005). Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes. Hormone and Metabolic Research. 37(7), 455-459. https://doi.org/10.1055/s-2005-870240