Journalartikel

Jahr der Veröffentlichung: 2005

Seiten: 534-537

Zeitschrift: Experimental and Clinical Endocrinology & Diabetes

Bandnummer: 113

Heftnummer: 9

ISSN: 0947-7349

DOI Link: https://doi.org/10.1055/s-2005-872851

Verlag: Thieme Publishing

Abstract: 
Abnormal glucose tolerance is associated with subclinical chronic inflammation in patients with type 2 diabetes. The aim of this study was to investigate whether plasma concentrations of inflammatory markers are associated with measures of obesity, insulin sensitivity, and hyperglycemia. IL-6, adiponectin, CRP, and IL-10 plasma concentrations were evaluated in 142 patients with a wide range of obesity, insulin sensitivity and glucose tolerance. In parallel with the impairment of glucose tolerance, there was a significant increase in IL-6, and CRP, and a significant decrease in adiponectin and IL-10 plasma concentrations. There were significant correlations between the plasma concentrations of all inflammatory markers and % body fat, insulin sensitivity, and fasting plasma glucose. However, multivariate linear regression analysis identified insulin sensitivity as determined by glucose infusion rate during the steady state of an euglycemic-hyperinsulinemic clamp as the strongest predictor of adiponectin, CRP, IL-6, and IL-10 plasma concentrations. In addition, fasting plasma glucose was a significant determinant of adiponectin, CRP, and IL-6 plasma concentrations, whereas body fat content was only a significant predictor of CRP plasma concentration. In conclusion, our data suggest that abnormal inflammatory markers in patients with type 2 diabetes are primarily related to decreased insulin sensitivity.

Harvard-Zitierstil: Blüher, M., Fasshauer, M., Tönjes, A., Kratzsch, J., Schön, M. and Paschke, R. (2005) Association of interleukin-6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity, insulin sensitivity and glucose metabolism, Experimental and Clinical Endocrinology & Diabetes, 113(9), pp. 534-537. https://doi.org/10.1055/s-2005-872851

APA-Zitierstil: Blüher, M., Fasshauer, M., Tönjes, A., Kratzsch, J., Schön, M., & Paschke, R. (2005). Association of interleukin-6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity, insulin sensitivity and glucose metabolism. Experimental and Clinical Endocrinology & Diabetes. 113(9), 534-537. https://doi.org/10.1055/s-2005-872851