Journal article

Publication year: 2002

Pages: R1-R8

Journal: Journal of Endocrinology

Volume number: 173

Issue number: 2

ISSN: 0022-0795

DOI Link: https://doi.org/10.1677/joe.0.173R001

Publisher: BioScientifica

Abstract: 
Ciliary neurotrophic factor (CNTF) plays an important role in regulating neuronal growth. Recently, central anorexigenic effects of this cytokine have been characterized. However, peripheral effects, on tissues that actively contribute to the regulation of energy homeostasis have not been described. Here, we report direct potent and selective effects of CNTF on growth factor and metabolic signalling intermediates in mouse brown adipocytes. CNTF stimulates STAT3, MAP kinase, Akt, and p70 S6 kinase. We find that, next to mediating Akt and p7() S6 kinase activation, both phosphatidylinositol 3-kinase and protein kinase C are separately acting, main intermediates for inducing mitogen-activated protein (MAP) kinase activation. On a functional level, CNTF enhances beta3-adrenergic induction Of uncoupling protein-1. Thus, these results demonstrate direct effects of CNTF on adipose tissue signalling and metabolism and suggest a novel role for this cytokine in the peripheral regulation of energy homeostasis.

Harvard Citation style: Ott, V., Fasshauer, M., Dalski, A., Klein, H. and Klein, J. (2002) Direct effects of ciliary neurotrophic factor on brown adipocytes: evidence for a role in peripheral regulation of energy homeostasis, Journal of Endocrinology, 173(2), pp. R1-R8. https://doi.org/10.1677/joe.0.173R001

APA Citation style: Ott, V., Fasshauer, M., Dalski, A., Klein, H., & Klein, J. (2002). Direct effects of ciliary neurotrophic factor on brown adipocytes: evidence for a role in peripheral regulation of energy homeostasis. Journal of Endocrinology. 173(2), R1-R8. https://doi.org/10.1677/joe.0.173R001