Ciliary neurotrophic factor influences endocrine adipocyte function: inhibition of leptin via PI 3-kinase - Research portal of Justus Liebig University Giessen:

Journal article

Ciliary neurotrophic factor influences endocrine adipocyte function: inhibition of leptin via PI 3-kinase

Authors list: Ott, V; Fasshauer, M; Meier, B; Dalski, A; Kraus, D; Gettys, TW; Perwitz, N; Klein, J

Publication year: 2004

Pages: 21-27

Journal: Molecular and Cellular Endocrinology

Volume number: 224

Issue number: 1-2

ISSN: 0303-7207

DOI Link: https://doi.org/10.1016/j.mce.2004.07.006

Publisher: Elsevier

Abstract:
Ciliary neurotrophic factor (CNTF), originally known for its involvement in the modulation of neuronal growth, has been discovered to exert anorexigenic effects and is currently being investigated in clinical studies for the treatment of obesity and insulin resistance. This neuropeptide acts on the central nervous system. However, we have recently demonstrated direct peripheral effects on adipocyte signalling and thermogenesis. Given the emerging endocrine role of adipose tissue in the regulation of energy homeostasis and insulin resistance, we investigated potential effects of CNTF on leptin expression and secretion. Our study demonstrates a direct inhibition of leptin expression and secretion by acute and chronic CNTF treatment. Furthermore, we demonstrate a differentiation- and Janus kinase 2 (JAK2)-independent, but phosphatidylinositol 3-kinase-dependent signalling pathway mediating this negative effect. These results provide novel evidence for a role of CNTF in the selective modulation of adipocyte endocrine function which may have important implications for the regulation of energy homeostasis. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

Authors/Editors

- Uni.-Prof. Dr. Mathias Faßhauer

Citation Styles

Harvard Citation style: Ott, V., Fasshauer, M., Meier, B., Dalski, A., Kraus, D., Gettys, T., et al. (2004) Ciliary neurotrophic factor influences endocrine adipocyte function: inhibition of leptin via PI 3-kinase, Molecular and Cellular Endocrinology, 224(1-2), pp. 21-27. https://doi.org/10.1016/j.mce.2004.07.006

APA Citation style: Ott, V., Fasshauer, M., Meier, B., Dalski, A., Kraus, D., Gettys, T., Perwitz, N., & Klein, J. (2004). Ciliary neurotrophic factor influences endocrine adipocyte function: inhibition of leptin via PI 3-kinase. Molecular and Cellular Endocrinology. 224(1-2), 21-27. https://doi.org/10.1016/j.mce.2004.07.006