Journal article

Publication year: 2005

Pages: 863-872

Journal: Expert Opinion on Pharmacotherapy

Volume number: 6

Issue number: 6

ISSN: 1465-6566

DOI Link: https://doi.org/10.1517/14656566.6.6.863

Publisher: Taylor and Francis Group

Abstract: 
Various adipocyte-secreted factors have been described which profoundly affect insulin sensitivity and might potentially link obesity, insulin resistance and cardiovascular disease. Among those, adiponectin, visfatin and omentin appear as insulin-sensitising adipocytokines, whereas TNF-alpha, IL-6 and resistin induce insulin resistance. Moreover, leptin is a fat-derived key regulator of appetite and energy expenditure. Due to their profound effect on whole-body glucose and energy metabolism, adipocytokines have attracted interest as potential new therapeutics for diabetes mellitus and obesity. The current knowledge on function, regulation and therapeutic potential of various adipocytokines, as well as their clinical implications, are discussed in this review.

Harvard Citation style: Kralisch, S., Klein, J., Blüher, M., Paschke, R., Stumvoll, M. and Fasshauer, M. (2005) Therapeutic perspectives of adipocytokines, Expert Opinion on Pharmacotherapy, 6(6), pp. 863-872. https://doi.org/10.1517/14656566.6.6.863

APA Citation style: Kralisch, S., Klein, J., Blüher, M., Paschke, R., Stumvoll, M., & Fasshauer, M. (2005). Therapeutic perspectives of adipocytokines. Expert Opinion on Pharmacotherapy. 6(6), 863-872. https://doi.org/10.1517/14656566.6.6.863