Journalartikel

Jahr der Veröffentlichung: 2008

Seiten: 657-659

Zeitschrift: Inform -Champaign-

Bandnummer: 19

Heftnummer: 10

Verlag: American Oil Chemists Society

Abstract: 

Although oxidized fats are widely considered to have detrimental effects on human health, feeding experiments in rats have consistently demonstrated that oxidized fats cause a reduction in the concentrations of triacylglycerols (TAG) and cholesterol in liver, plasma, and very low-density lipoproteins (VLDL). Subsequently, many genes involved in β-oxidation of FA including carnitine palmitoyltransferases (CPT), which supply acetyl-CoA used for the generation of ATP via the citrate cycle and for the generation of ketone bodies, an important fuel for the brain during fasting, are up-regulated.\n Insig are membrane proteins that reside in the endoplasmic reticulum and play a central role in the regulation of SREBP activation, because they prevent the translocation of SREBP from the endoplasmic reticulum to the Golgi, where proteolytic activation of SREBP and subsequent release of transcriptionally active forms of SREBP occur. 

Harvard-Zitierstil: Ringseis, R., Eder and K (2008) Effects of dietary oxidized fats on gene expression in mammals Examining the central role of peroxisome proliferator-activated receptors, Inform -Champaign-, 19(10), pp. 657-659

APA-Zitierstil: Ringseis, R., Eder, & K (2008). Effects of dietary oxidized fats on gene expression in mammals Examining the central role of peroxisome proliferator-activated receptors. Inform -Champaign-. 19(10), 657-659.