Journalartikel

Jahr der Veröffentlichung: 2006

Seiten: 2641-2648

Zeitschrift: Rapid Communications in Mass Spectrometry

Bandnummer: 20

Heftnummer: 18

ISSN: 0951-4198

DOI Link: https://doi.org/10.1002/rcm.2650

Verlag: Wiley

Abstract: 
Active phloroglucinol constituents of Hypericum perforatum (St. John's wort) extracts, hyperforin and adhyperforin, have been studied following ion activation using tandem mass spectrometry (MS/MS) and complemented by accurate mass measurements. These two compounds were readily analyzed as protonated and deprotonated molecules with electrospray ionization. MS/MS and MS3 data from a quadrupole-linear ion trap tandem mass spectrometer were employed to elucidate fragmentation pathways. Fourier transform ion cyclotron resonance measurements afforded excellent mass accuracies for the confirmation of elemental formulae of product ions formed via infrared multiphoton dissociation and sustained off-resonance irradiation collision-induced dissociation. Fragmentation schemes have been devised for the dissociation of hyperforin and adhyperforin in negative and positive ion modes. This information is expected to be especially valuable for the characterization of related compounds, such as degradation products, metabolites and novel synthetic analogs of hyperforin. Copyright (c) 2006 John Wiley & Sons, Ltd.

Harvard-Zitierstil: Sleno, L., Daneshfar, R., Eckert, G., Müller, W. and Volmer, D. (2006) Mass spectral characterization of phloroglucinol derivatives hyperforin and adhyperforin, Rapid Communications in Mass Spectrometry, 20(18), pp. 2641-2648. https://doi.org/10.1002/rcm.2650

APA-Zitierstil: Sleno, L., Daneshfar, R., Eckert, G., Müller, W., & Volmer, D. (2006). Mass spectral characterization of phloroglucinol derivatives hyperforin and adhyperforin. Rapid Communications in Mass Spectrometry. 20(18), 2641-2648. https://doi.org/10.1002/rcm.2650