Journal article

Publication year: 2007

Pages: 438-445

Journal: Neurobiology of Disease

Volume number: 25

Issue number: 2

ISSN: 0969-9961

DOI Link: https://doi.org/10.1016/j.nbd.2006.10.004

Publisher: Elsevier

Abstract: 
The present study determined if chronic simvastatin administration in vivo would provide neuroprotection in brain cells isolated from guinea pigs after challenge with the Bel-2 inhibitor HA 14-1 or the NO donor sodium nitroprusside (SNP). Bcl-2 levels were significantly increased in brains of simvastatin-treated guinea pigs while levels of the proapoptotic protein Bax were significantly reduced. The ratio of Bax/Bcl-2, being a critical factor of the apoptotic state of cells, was significantly reduced in simvastatin-treated animals. Cholesterol levels in the brain remained unchanged in the simvastatin group. Brain cells isolated from simvastatin-treated guinea pigs were significantly less vulnerable to mitochondrial dysfunction and caspase-activation. These results provide new insight into potential mechanisms for the protective actions of statins within the CNS where programmed cell death has been implicated. (c) 2006 Elsevier Inc. All rights reserved.

Harvard Citation style: Franke, C., Nöldner, M., Abdel-Kader, R., Johnson-Anuna, L., Wood, W., Müller, W., et al. (2007) Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment, Neurobiology of Disease, 25(2), pp. 438-445. https://doi.org/10.1016/j.nbd.2006.10.004

APA Citation style: Franke, C., Nöldner, M., Abdel-Kader, R., Johnson-Anuna, L., Wood, W., Müller, W., & Eckert, G. (2007). Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment. Neurobiology of Disease. 25(2), 438-445. https://doi.org/10.1016/j.nbd.2006.10.004