Journal article

Publication year: 2009

Pages: 673-677

Journal: Biochemical and Biophysical Research Communications

Volume number: 382

Issue number: 4

ISSN: 0006-291X

DOI Link: https://doi.org/10.1016/j.bbrc.2009.03.070

Publisher: Elsevier

Abstract: 
Protein-lipid interactions in the nervous system may provide insight into the causes of neurological disorders. In this study, we elucidated if expression of human presenilin 1 (PS1) in a mouse model changes the physico-chemical properties of brain membranes. PS1 is a multifunctional transmembrane protein and part of the gamma-secretase complex. This complex is critical for the production of the Alzheimer related amyloid beta peptide. Brain membranes isolated from mice expressing a human wild-type PS1 transgene are less fluid and contain higher cholesterol and sphingomyelin levels. Moreover, our data reveal significant changes in membrane micro-domains and indicate that PS1 induces the formation of lipid rafts. (C) 2009 Elsevier Inc. All rights reserved.

Harvard Citation style: Eckert, G. and Müller, W. (2009) Presenilin 1 modifies lipid raft composition of neuronal membranes, Biochemical and Biophysical Research Communications, 382(4), pp. 673-677. https://doi.org/10.1016/j.bbrc.2009.03.070

APA Citation style: Eckert, G., & Müller, W. (2009). Presenilin 1 modifies lipid raft composition of neuronal membranes. Biochemical and Biophysical Research Communications. 382(4), 673-677. https://doi.org/10.1016/j.bbrc.2009.03.070