Journalartikel

Jahr der Veröffentlichung: 2011

Seiten: 161-163

Zeitschrift: Pharmacopsychiatry

Bandnummer: 44

Heftnummer: 4

ISSN: 0176-3679

DOI Link: https://doi.org/10.1055/s-0031-1279731

Verlag: Georg Thieme Verlag

Abstract: 
Recent findings showing significant correlations between phospholipase A2 (PLA2) activity and structural changes in schizophrenic brains contribute to the membrane hypothesis of schizophrenia, which was hampered because a clean functional link between elevated PLA2 activity and brain structure was missing (Neuroimage, 2010; 52: 1314-1327). We measured membrane fluidity parameters and found that brain membranes isolated from the prefrontal cortex of schizophrenic patients showed significantly increased flexibility of fatty acid chains. Our findings support a possible link between elevated PLA2 activity in cortical areas of schizophrenic patients and subsequent alterations of the biophysical parameters of neuronal membranes leading to structural changes in these areas.

Harvard-Zitierstil: Eckert, G., Schaeffer, E., Schmitt, A., Maras, A. and Gattaz, W. (2011) Increased Brain Membrane Fluidity in Schizophrenia, Pharmacopsychiatry, 44(4), pp. 161-163. https://doi.org/10.1055/s-0031-1279731

APA-Zitierstil: Eckert, G., Schaeffer, E., Schmitt, A., Maras, A., & Gattaz, W. (2011). Increased Brain Membrane Fluidity in Schizophrenia. Pharmacopsychiatry. 44(4), 161-163. https://doi.org/10.1055/s-0031-1279731