Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components - Research portal of Justus Liebig University Giessen:

Journal article

Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components

Authors list: Hagl, S; Berressem, D; Bruns, B; Sus, N; Frank, J; Eckert, GP

Publication year: 2015

Pages: 16524-16539

Journal: Molecules

Volume number: 20

Issue number: 9

ISSN: 1420-3049

DOI Link: https://doi.org/10.3390/molecules200916524

Publisher: MDPI

Abstract:
Mitochondria are involved in the aging processes that ultimately lead to neurodegeneration and the development of Alzheimer's disease (AD). A healthy lifestyle, including a diet rich in antioxidants and polyphenols, represents one strategy to protect the brain and to prevent neurodegeneration. We recently reported that a stabilized hexanic rice bran extract (RBE) rich in vitamin E and polyphenols (but unsuitable for human consumption) has beneficial effects on mitochondrial function in vitro and in vivo (doi:10.1016/j.phrs.2013.06.008, 10.3233/JAD-132084). To enable the use of RBE as food additive, a stabilized ethanolic extract has been produced. Here, we compare the vitamin E profiles of both extracts and their effects on mitochondrial function (ATP concentrations, mitochondrial membrane potential, mitochondrial respiration and mitochondrial biogenesis) in PC12 cells. We found that vitamin E contents and the effects of both RBE on mitochondrial function were similar. Furthermore, we aimed to identify components responsible for the mitochondria-protective effects of RBE, but could not achieve a conclusive result. -Tocotrienol and possibly also -tocotrienol, -tocopherol and -tocopherol might be involved, but hitherto unknown components of RBE or a synergistic effect of various components might also play a role in mediating RBE's beneficial effects on mitochondrial function.

Citation Styles

Harvard Citation style: Hagl, S., Berressem, D., Bruns, B., Sus, N., Frank, J. and Eckert, G. (2015) Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components, Molecules, 20(9), pp. 16524-16539. https://doi.org/10.3390/molecules200916524

APA Citation style: Hagl, S., Berressem, D., Bruns, B., Sus, N., Frank, J., & Eckert, G. (2015). Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components. Molecules. 20(9), 16524-16539. https://doi.org/10.3390/molecules200916524