Journalartikel

Jahr der Veröffentlichung: 2001

Seiten: 617-623

Zeitschrift: Biochemical Society Transactions

Bandnummer: 29

Heftnummer: 4

ISSN: 0300-5127

DOI Link: https://doi.org/10.1042/BST0290617

Verlag: Portland Press

Abstract: 

beta-Amyloid (A beta) protein is the major constituent of senile plaques and cerebrovascular deposits characteristic of Alzheimer's disease (AD). The causal relationship between A beta and AD-specific lesions like neurodegeneration and atrophy is still not known. The present article summarizes our studies indicating that rather low concentrations of A beta significantly alter the fluidity of cell membranes and subcellular fractions from different tissues and different species including humans, as a possible initial step of its biological effects. Using different fluorescent probes our data show clearly that A beta peptides specifically disturb the acylchain layer of cell membranes in a very distinct fashion. By contrast, membrane properties at the level of the polar heads of the phospholipid bilayer at the interface with membrane proteins are much less affected.

Harvard-Zitierstil: Müller, W., Kirsch, C. and Eckert, G. (2001) Membrane-disordering effects of beta-amyloid peptides, Biochemical Society Transactions, 29(4), pp. 617-623. https://doi.org/10.1042/BST0290617

APA-Zitierstil: Müller, W., Kirsch, C., & Eckert, G. (2001). Membrane-disordering effects of beta-amyloid peptides. Biochemical Society Transactions. 29(4), 617-623. https://doi.org/10.1042/BST0290617