Journal article

Publication year: 2012

Pages: 2314-2323

Journal: Current Topics in Medicinal Chemistry

Volume number: 12

Issue number: 21

ISSN: 1568-0266

DOI Link: https://doi.org/10.2174/156802612805289845

Publisher: Bentham Science Publishers

Abstract: 
Physiological enzymatic cleavage of membrane phospholipids by phospholipase A(2) (PLA(2)) results in normal levels of phosphomonoester and phosphodiester, by which a normal dopamine neurotransmission is maintained. Data from postmortem tissue and in vivo imaging studies suggest that increased activity of intracellular calcium-independent PLA(2) (iPLA(2)) in the brain of schizophrenic patients might accelerate the breakdown of membrane phospholipids and alter the properties of neuronal membranes, which in turn contributes to a hypodopaminergy. Alterations in PLA(2) activity are probably genetically determined and represent a possible pharmacological target for Schizophrenia.

Harvard Citation style: Schaeffer, E., Gattaz, W. and Eckert, G. (2012) Alterations of Brain Membranes in Schizophrenia: Impact of Phospholipase A2, Current Topics in Medicinal Chemistry, 12(21), pp. 2314-2323. https://doi.org/10.2174/156802612805289845

APA Citation style: Schaeffer, E., Gattaz, W., & Eckert, G. (2012). Alterations of Brain Membranes in Schizophrenia: Impact of Phospholipase A2. Current Topics in Medicinal Chemistry. 12(21), 2314-2323. https://doi.org/10.2174/156802612805289845