Contribution in an anthology

Appeared in: The mitochondria in aging and disease

Editor list: Osiewacz, HD

Publication year: 2014

Pages: 183-210

ISBN: 978-0-12-394625-6

DOI Link: https://doi.org/10.1016/B978-0-12-394625-6.00007-6

Edition: 1. ed.

Title of series: Progress in molecular biology and translational science

Number in series: 127

Abstract: 

The etiology of common, nonfamiliar late-onset Alzheimer's disease (LOAD) is only partly understood and seems to be extremely complex including many genetic and environmental factors. The most important environmental risk factor to develop LOAD is aging itself. Aging and LOAD are considered to be strongly linked to mitochondrial dysfunction and enhanced oxidative stress. In this review, we focus on the interaction between mitochondrial dysfunction in aging especially on defects of the respiratory chain of the oxidative phosphorylation system resulting in enhanced oxidative stress and the interplay between aging-associated mitochondrial defects and LOAD-associated mitochondrial failure. The deleterious effects of the two hallmarks of LOAD, amyloid beta, and hyperphosphorylated tau, on mitochondrial function, movement, and morphology are described as well as the toxic effects of the most relevant genetic risk factor of LOAD, the apolipoprotein E4 allele. Finally, the review provides an overview about drugs and nutritional ingredients which improve mitochondrial function or/and act as antioxidants and discusses their potential role in the treatment of LOAD.

Harvard Citation style: Friedland-Leuner, K., Stockburgert, C., Denzer, I., Eckert, G. and Müller, W. (2014) Mitochondrial Dysfunction: Cause and Consequence of Alzheimer's Disease, in Osiewacz, H. (ed.) The mitochondria in aging and disease. 1. ed. . Amsterdam: Acad.Press, pp. 183-210. https://doi.org/10.1016/B978-0-12-394625-6.00007-6

APA Citation style: Friedland-Leuner, K., Stockburgert, C., Denzer, I., Eckert, G., & Müller, W. (2014). Mitochondrial Dysfunction: Cause and Consequence of Alzheimer's Disease. In Osiewacz, H. (Ed.), The mitochondria in aging and disease (1. ed. , pp. 183-210). Acad.Press. https://doi.org/10.1016/B978-0-12-394625-6.00007-6