Sammelbandbeitrag

Erschienen in: Handbook of Neurochemistry and Molecular Neurobiology : Neural Membranes and Transport

Herausgeberliste: Reith, MEA; Lajtha, A

Jahr der Veröffentlichung: 2009

Seiten: 151-170

ISBN: 978-0-387-30347-5

eISBN: 978-0-387-30380-2

DOI Link: https://doi.org/10.1007/978-0-387-30380-2_7

Auflage: 1. ed.

Abstract: 

Understanding the role of cholesterol in normal brain function and its involvement in specific neurodegenerative diseases has attracted considerable attention. One general observation is that there are notable differences in the brain cholesterol properties and dynamics as compared with cholesterol outside of the brain. In addition, much of what is known of brain cholesterol is based on studies focusing on the total or bulk amount of cholesterol; however, it is becoming increasingly recognized that cholesterol domains may provide greater insight into the cellular function of cholesterol. This chapter, therefore, examines the role of cholesterol in brain, compares the properties and dynamics of brain and peripheral cholesterol, and describes cholesterol domains and the contribution of cholesterol to brain pathophysiology, with an emphasis on Alzheimer's disease (AD). Attention is also directed at the participation of other compounds in the brain cholesterol biosynthetic pathway, namely isoprenoids and the cholesterol metabolites, oxysterols.

Harvard-Zitierstil: Wood, W., Igbavboa, U., eckert, G. and Müller, W. (2009) Cholesterol—A Janus-Faced Molecule in the Central Nervous System, in Reith, M. and Lajtha, A. (eds.) Handbook of Neurochemistry and Molecular Neurobiology : Neural Membranes and Transport. 1. ed.. Berlin: Springer US, pp. 151-170. https://doi.org/10.1007/978-0-387-30380-2_7

APA-Zitierstil: Wood, W., Igbavboa, U., eckert, G., & Müller, W. (2009). Cholesterol—A Janus-Faced Molecule in the Central Nervous System. In Reith, M., & Lajtha, A. (Eds.), Handbook of Neurochemistry and Molecular Neurobiology : Neural Membranes and Transport (1. ed., pp. 151-170). Springer US. https://doi.org/10.1007/978-0-387-30380-2_7