Journal article
Authors list: Silano, V; Baviera, JMB; Bolognesi, C; Brüschweiler, BJ; Cocconcelli, PS; Crebelli, R; Gott, DM; Grob, K; Lampi, E; Mortensen, A; Riviere, G; Steffensen, IL; Tlustos, C; van Loveren, H; Vernis, L; Zorn, H; Glandorf, B; Penninks, A; Zeljezic, D; Gomes, A; Engel, KH; Chesson, A
Publication year: 2019
Pages: 5738-
Journal: EFSA Journal
Volume number: 17
Issue number: 6
DOI Link: https://doi.org/10.2903/j.efsa.2019.5738
Publisher: Wiley
Abstract:
The food enzyme alpha-amylase (1,4-alpha-D-glucan glucanohydrolase; EC 3.2.1.1) is produced with the genetically modified Bacillus licheniformis strain DP-Dzb44 by Danisco US Inc. The production strain of the food enzyme contains multiple copies of a known antimicrobial resistance gene. However, based on the absence of viable cells and DNA from the production organism in the food enzyme, this is not considered to be a risk. The alpha-amylase is intended to be used in distilled alcohol production. Since residual amounts of the food enzyme are removed by distillation, toxicological studies were not considered necessary and no dietary exposure was calculated. Similarity of the amino acid sequence to those of known allergens was searched and one match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions can be excluded. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use. (C) 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Citation Styles
Harvard Citation style: Silano, V., Baviera, J., Bolognesi, C., Brüschweiler, B., Cocconcelli, P., Crebelli, R., et al. (2019) Safety evaluation of the food enzyme alpha-amylase from Bacillus licheniformis (strain DP-Dzb44), EFSA Journal, 17(6), p. 5738. https://doi.org/10.2903/j.efsa.2019.5738
APA Citation style: Silano, V., Baviera, J., Bolognesi, C., Brüschweiler, B., Cocconcelli, P., Crebelli, R., Gott, D., Grob, K., Lampi, E., Mortensen, A., Riviere, G., Steffensen, I., Tlustos, C., van Loveren, H., Vernis, L., Zorn, H., Glandorf, B., Penninks, A., Zeljezic, D., ...Chesson, A. (2019). Safety evaluation of the food enzyme alpha-amylase from Bacillus licheniformis (strain DP-Dzb44). EFSA Journal. 17(6), 5738. https://doi.org/10.2903/j.efsa.2019.5738
