Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63) - Research portal of Justus Liebig University Giessen:

Journal article

Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63)

Authors list: Silano, V; Barat, JM; Bolognesi, C; Cocconcelli, PS; Crebelli, R; Gott, DM; Grob, K; Lampi, E; Mortensen, A; Riviere, G; Steffensen, IL; Tlustos, C; van Loveren, H; Vernis, L; Zorn, H; Glandorf, B; Herman, L; Aguilera, J; Andryszkiewicz, M; Liu, Y; Chesson, A

Publication year: 2019

Pages: 5825-

Journal: EFSA Journal

Volume number: 17

Issue number: 10

DOI Link: https://doi.org/10.2903/j.efsa.2019.5825

Publisher: Wiley

Abstract:
The food enzyme 4-alpha-D-glucan glucohydrolase (EC 3.2.1.3) is produced with a genetically modified Trichoderma reesei DP-Nzh63 by Danisco US Inc. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and recombinant DNA. The glucan 1,4-alpha-glucosidase is intended to be used in distilled alcohol production. Since residual amounts of total organic solids are removed by distillation (> 99%), toxicological data were not considered necessary and dietary exposure was not calculated. Similarity of the amino acid sequence to those of known allergens was searched and no matches were found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure can be excluded. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use. (C) 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

Authors/Editors

- Uni.-Prof. Dr. Holger Zorn

Citation Styles

Harvard Citation style: Silano, V., Barat, J., Bolognesi, C., Cocconcelli, P., Crebelli, R., Gott, D., et al. (2019) Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63), EFSA Journal, 17(10), p. 5825. https://doi.org/10.2903/j.efsa.2019.5825

APA Citation style: Silano, V., Barat, J., Bolognesi, C., Cocconcelli, P., Crebelli, R., Gott, D., Grob, K., Lampi, E., Mortensen, A., Riviere, G., Steffensen, I., Tlustos, C., van Loveren, H., Vernis, L., Zorn, H., Glandorf, B., Herman, L., Aguilera, J., Andryszkiewicz, M., ...Chesson, A. (2019). Safety evaluation of the food enzyme glucan 1,4‐α‐glucosidase from Trichoderma reesei (strain DP‐Nzh63). EFSA Journal. 17(10), 5825. https://doi.org/10.2903/j.efsa.2019.5825