Journal article
Authors list: Silano, V; Baviera, JMB; Bolognesi, C; Bruschweiler, BJ; Cocconcelli, PS; Crebelli, R; Gott, DM; Grob, K; Lampi, E; Mortensen, A; Riviere, G; Steffensen, IL; Tlustos, C; Van Loveren, H; Vernis, L; Zorn, H; Glandorf, B; Herman, L; Marcon, F; Penninks, A; Smith, A; Aguilera, J; Kovalkovicova, N; Liu, Y; Maia, J; Engel, KH; Chesson, A
Publication year: 2019
Pages: 5547-
Journal: EFSA Journal
Volume number: 17
Issue number: 1
DOI Link: https://doi.org/10.2903/j.efsa.2019.5547
Publisher: Wiley
Abstract:
The food enzyme is a glucose isomerase (d-xylose aldose-ketose-isomerase; EC 5.3.1.5) produced with a non-genetically modified Streptomycesmurinus strain NZYM-GA by Novozymes A/S. The glucose isomerase is intended only to be used in an immobilised form in glucose isomerisation for the production of high fructose syrups. Residual amounts of total organic solids are removed by the purification steps applied during the production of high fructose syrups using the immobilised enzyme; consequently, dietary exposure was not calculated. Genotoxicity tests did not raise a safety concern. Similarity of the amino acid sequence to those of known allergens was searched and no match was found. The Panelconsidered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood to occur is considered to be low. Based on the data provided, the immobilisation process and the removal of total organic solids during the production of high fructose syrups, the Panelconcluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
Citation Styles
Harvard Citation style: Silano, V., Baviera, J., Bolognesi, C., Bruschweiler, B., Cocconcelli, P., Crebelli, R., et al. (2019) Safety evaluation of the food enzyme glucose isomerase from Streptomyces murinus (strain NZYM-GA), EFSA Journal, 17(1), p. 5547. https://doi.org/10.2903/j.efsa.2019.5547
APA Citation style: Silano, V., Baviera, J., Bolognesi, C., Bruschweiler, B., Cocconcelli, P., Crebelli, R., Gott, D., Grob, K., Lampi, E., Mortensen, A., Riviere, G., Steffensen, I., Tlustos, C., Van Loveren, H., Vernis, L., Zorn, H., Glandorf, B., Herman, L., Marcon, F., ...Chesson, A. (2019). Safety evaluation of the food enzyme glucose isomerase from Streptomyces murinus (strain NZYM-GA). EFSA Journal. 17(1), 5547. https://doi.org/10.2903/j.efsa.2019.5547
