Journal article
Authors list: Silano, V; Baviera, JMB; Bolognesi, C; Cocconcelli, PS; Crebelli, R; Gott, DM; Grob, K; Lambre, C; Lampi, E; Mengelers, M; Mortensen, A; Riviere, G; Steffensen, IL; Tlustos, C; Van Loveren, H; Vernis, L; Zorn, H; Herman, L; Gomes, A; Andryszkiewicz, M; Kovalkovicova, N; Liu, Y; Chesson, A
Publication year: 2020
Pages: 6185-
Journal: EFSA Journal
Volume number: 18
Issue number: 10
DOI Link: https://doi.org/10.2903/j.efsa.2020.6185
Publisher: Wiley
Abstract:
The food enzyme alpha-amylase (4-alpha-D-glucan glucohydrolase; EC 3.2.1.1) is produced with the genetically modified B. amyloliquefaciens strain DP-Czb53 by Danisco US Inc. The genetic modifications do not raise safety concerns, except for the presence of a multicopy plasmid carrying known antimicrobial resistance genes. However, based on the absence of viable cells and DNA from the production organism in the food enzyme, this is not considered to be a risk. The food enzyme is intended to be used in starch processing for the production of glucose syrups. Toxicological studies and dietary exposure estimation were not considered necessary. Similarity of the amino acid sequence to those of known allergens was searched and one match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use. (C) 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Citation Styles
Harvard Citation style: Silano, V., Baviera, J., Bolognesi, C., Cocconcelli, P., Crebelli, R., Gott, D., et al. (2020) Safety evaluation of the food enzyme alpha-amylase from the genetically modified Bacillus amyloliquefaciens strain DP-Czb53, EFSA Journal, 18(10), p. 6185. https://doi.org/10.2903/j.efsa.2020.6185
APA Citation style: Silano, V., Baviera, J., Bolognesi, C., Cocconcelli, P., Crebelli, R., Gott, D., Grob, K., Lambre, C., Lampi, E., Mengelers, M., Mortensen, A., Riviere, G., Steffensen, I., Tlustos, C., Van Loveren, H., Vernis, L., Zorn, H., Herman, L., Gomes, A., ...Chesson, A. (2020). Safety evaluation of the food enzyme alpha-amylase from the genetically modified Bacillus amyloliquefaciens strain DP-Czb53. EFSA Journal. 18(10), 6185. https://doi.org/10.2903/j.efsa.2020.6185
