Journal article

Publication year: 2020

Pages: 6328-6339

Journal: European Journal of Organic Chemistry

Volume number: 2020

Issue number: 40

ISSN: 1434-193X

Open access status: Hybrid

DOI Link: https://doi.org/10.1002/ejoc.202000711

Publisher: Wiley

Abstract: 
Knowledge of absolute configurations (ACs) is crucial to understand the properties and functions of chiral molecules. Although the development of asymmetric reactions has enabled access to a large variety of enantioenriched compounds, stereochemical assignments of chiral molecules, especially chiral alkanes, remain challenging. In this Minireview, we first summarize common analytical techniques for AC determination with a focus on chiral alkanes as analytical targets. Next, we describe some of our efforts over the last 20 years on syntheses and AC determination of chiral alkanes including [123]tetramantane, hexadeuterated neopentane, and trans-perhydroazulene. Lastly, microscopic techniques and the crystalline sponge method are discussed as particularly promising approaches to revolutionize the field of stereochemical analysis.

Harvard Citation style: Saito, F. and Schreiner, P. (2020) Determination of the Absolute Configurations of Chiral Alkanes - An Analysis of the Available Tools, European Journal of Organic Chemistry, 2020(40), pp. 6328-6339. https://doi.org/10.1002/ejoc.202000711

APA Citation style: Saito, F., & Schreiner, P. (2020). Determination of the Absolute Configurations of Chiral Alkanes - An Analysis of the Available Tools. European Journal of Organic Chemistry. 2020(40), 6328-6339. https://doi.org/10.1002/ejoc.202000711