Journalartikel

Jahr der Veröffentlichung: 2020

Seiten: 14009-14016

Zeitschrift: Dalton Transactions

Bandnummer: 49

Heftnummer: 40

ISSN: 1477-9226

DOI Link: https://doi.org/10.1039/d0dt02391d

Verlag: Royal Society of Chemistry

Abstract: 
Platinum-based antineoplastic agents play a major role in the treatment of numerous types of cancer. A new bulky, lipophilic, and chiral ligand based on 1,2-diaminodiamantane in both of its enantiomeric forms was employed for the preparation of new platinum(II) complexes with chloride and oxalate ligands. The dichloride complexes have a higher solubility and were evaluated as anti-proliferation agents for human ovarian cancer cell lines A2780 and cisplatin-resistant A2780cis. Its R,R-enantiomer showed increased efficacy compared to cisplatin for both cancer cell lines. A chromatographic approach was used to estimate the solvent partition coefficient of the dichloride complex. The binding of diamondoid-based platinum complexes to nucleotides was tested for both enantiomers with guanosine monophosphate (GMP) and deoxyguanosine monophosphate (dGMP) and occurs at a similar or faster rate for both isomers compared to cisplatin despite greatly increased steric demand. These findings highlight the potential in 1,2-diaminodiamantane as a viable pharmacophore.

Harvard-Zitierstil: Bakhonsky, V., Pashenko, A., Becker, J., Hausmann, H., De Groot, H., Overkleeft, H., et al. (2020) Synthesis and antiproliferative activity of hindered, chiral 1,2-diaminodiamantane platinum(II) complexes, Dalton Transactions, 49(40), pp. 14009-14016. https://doi.org/10.1039/d0dt02391d

APA-Zitierstil: Bakhonsky, V., Pashenko, A., Becker, J., Hausmann, H., De Groot, H., Overkleeft, H., Fokin, A., & Schreiner, P. (2020). Synthesis and antiproliferative activity of hindered, chiral 1,2-diaminodiamantane platinum(II) complexes. Dalton Transactions. 49(40), 14009-14016. https://doi.org/10.1039/d0dt02391d