Journal article

Publication year: 2020

Pages: 12358-12363

Journal: Chemical Science

Volume number: 11

Issue number: 45

Open access status: Gold

DOI Link: https://doi.org/10.1039/D0SC04906A

Publisher: Royal Society of Chemistry

Abstract: 

Amide tautomers, which constitute the higher-energy amide bond linkage, not only are key for a variety of biological but also prebiotic processes. In this work, we present the gas-phase synthesis of 1-aminoethenol, the higher-energy tautomer of acetamide, that has not been spectroscopically identified to date. The title compound was prepared by flash vacuum pyrolysis of malonamic acid and was characterized employing matrix isolation infrared as well as ultraviolet/visible spectroscopy. Coupled-cluster computations at the AE-CCSD(T)/cc-pVTZ level of theory support the spectroscopic assignments. Upon photolysis at λ > 270 nm, the enol rearranges to acetamide as well as ketene and ammonia. As the latter two are even higher in energy, they constitute viable starting materials for formation of the title compound.

Harvard Citation style: Mardyukov, A., Keul, F. and Schreiner, P. (2020) Preparation and characterization of the enol of acetamide: 1-aminoethenol, a high-energy prebiotic molecule, Chemical Science, 11(45), pp. 12358-12363 . https://doi.org/10.1039/D0SC04906A

APA Citation style: Mardyukov, A., Keul, F., & Schreiner, P. (2020). Preparation and characterization of the enol of acetamide: 1-aminoethenol, a high-energy prebiotic molecule. Chemical Science. 11(45), 12358-12363 . https://doi.org/10.1039/D0SC04906A