Journal article

Publication year: 2021

Pages: 104651-

Journal: Bioorganic Chemistry

Volume number: 108

DOI Link: https://doi.org/10.1016/j.bioorg.2021.104651

Publisher: Elsevier

Abstract: 

The reductive activity of various basidiomycetous fungi towards carbonyl compounds was screened on an analytical level. Some strains displayed high reductive activities toward aromatic carbonyls and aliphatic ketones. Utilizing growing whole-cell cultures of Dichomitus albidofuscus, the reactions were up-scaled to a preparative scale in an aqueous system. The reactions showed excellent selectivities and gave the respective alcohols in high yields. Carboxylic acids were also reduced to aldehydes and alcohols under the same conditions. In particular, benzoic, vanillic, ferulic, and p-coumaric acid were reduced to benzyl alcohol, vanillin, dihydroconiferyl alcohol and 1-hydroxy-3-(4-hydroxyphenyl)propan, respectively.

Harvard Citation style: Zhuk, T., Skorobohatko, O., Albuquerque, W. and Zorn, H. (2021) Scope and limitations of biocatalytic carbonyl reduction with white-rot fungi, Bioorganic Chemistry, 108, p. 104651. https://doi.org/10.1016/j.bioorg.2021.104651

APA Citation style: Zhuk, T., Skorobohatko, O., Albuquerque, W., & Zorn, H. (2021). Scope and limitations of biocatalytic carbonyl reduction with white-rot fungi. Bioorganic Chemistry. 108, 104651. https://doi.org/10.1016/j.bioorg.2021.104651