Journal article

Publication year: 2020

Pages: 227-

Journal: Marine Drugs

Volume number: 18

Issue number: 4

Open access status: Gold

DOI Link: https://doi.org/10.3390/md18040227

Publisher: MDPI

Abstract: 
Sponge-associated fungi are attractive targets for the isolation of bioactive natural products with different pharmaceutical purposes. In this investigation, 20 fungi were isolated from 10 different sponge specimens. One isolate, the fungus Penicillium citrinum strain WK-P9, showed activity against Bacillus subtilis JH642 when cultivated in malt extract medium. One new and three known citrinin derivatives were isolated from the extract of this fungus. The structures were elucidated by 1D and 2D NMR spectroscopy, as well as LC-HRMS. Their antibacterial activity against a set of common human pathogenic bacteria and fungi was tested. Compound 2 showed moderate activity against Mycobacterium smegmatis ATCC607 with a minimum inhibitory concentration (MIC) of 32 mu g/mL. Compound 4 exhibited moderate growth inhibition against Bacillus subtilis JH642, B. megaterium DSM32, and M. smegmatis ATCC607 with MICs of 16, 16, and 32 mu g/mL, respectively. Furthermore, weak activities of 64 mu g/mL against B. subtilis DSM10 and S. aureus ATCC25923 were observed for compound 4.

Harvard Citation style: Sabdaningsih, A., Liu, Y., Mettal, U., Heep, J., Riyanti, Wang, L., et al. (2020) A New Citrinin Derivative from the Indonesian Marine Sponge-Associated Fungus Penicillium citrinum, Marine Drugs, 18(4), p. 227. https://doi.org/10.3390/md18040227

APA Citation style: Sabdaningsih, A., Liu, Y., Mettal, U., Heep, J., Riyanti, Wang, L., Cristianawati, O., Nuryadi, H., Sibero, M., Marner, M., Radjasa, O., Sabdono, A., Trianto, A., & Schäberle, T. (2020). A New Citrinin Derivative from the Indonesian Marine Sponge-Associated Fungus Penicillium citrinum. Marine Drugs. 18(4), 227. https://doi.org/10.3390/md18040227