Journal article

Publication year: 2021

Pages: 2232-2241

Journal: Organic Chemistry Frontiers

Volume number: 8

Issue number: 10

ISSN: 2052-4129

DOI Link: https://doi.org/10.1039/d1qo00173f

Publisher: Royal Society of Chemistry

Abstract: 
Under the guidance of MS/MS based molecular networking, five new meroterpenoids (1-5), including three novel skeleton meroterpenoids, peniclactones A-C (1-3), and two new isoaustinone analogues, 6-hydroxyisoaustinone (4) and 6-ketoisoaustinone (5), were isolated from the fungus Penicillium sp. GDGJ-285. Their structures were elucidated by HRMS and NMR spectroscopy, and their absolute configurations were determined by X-ray single-crystal diffraction analysis. Peniclactones A-C (1-3) represent the first meroterpenoids featuring a 6/5/6/6/5/6 (1), 6/5/6/6/5/5 (2), and 6/5/6/5/5/6 (3) hexacyclic ring system, respectively. Bioassays showed that compound 3 inhibited nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with an IC50 value of 39.03 mu M.

Harvard Citation style: Mo, T., Huang, X., Zhang, W., Schäberle, T., Qin, J., Zhou, D., et al. (2021) A series of meroterpenoids with rearranged skeletons from an endophytic fungus Penicillium sp. GDGJ-285, Organic Chemistry Frontiers, 8(10), pp. 2232-2241. https://doi.org/10.1039/d1qo00173f

APA Citation style: Mo, T., Huang, X., Zhang, W., Schäberle, T., Qin, J., Zhou, D., Qin, X., Xu, Z., Li, J., & Yang, R. (2021). A series of meroterpenoids with rearranged skeletons from an endophytic fungus Penicillium sp. GDGJ-285. Organic Chemistry Frontiers. 8(10), 2232-2241. https://doi.org/10.1039/d1qo00173f