Journalartikel

Jahr der Veröffentlichung: 2020

Seiten: 532-536

Zeitschrift: Journal of Natural Products

Bandnummer: 83

Heftnummer: 2

ISSN: 0163-3864

DOI Link: https://doi.org/10.1021/acs.jnatprod.9b00886

Verlag: American Chemical Society

Abstract: 
A chemical investigation of the sponge Verongula cf. rigida led to the isolation of 13 merosesquiterpenes, among which quintaquinone (2), 5-epi-nakijiquinone L (3), and 3-farnesyl-2-hydroxy-5-methoxyquinone (4) were isolated and reported here for the first time. Particularly, compound 2 is the first member of merosesquiterpenes with a polyketide side chain substituted on C-19. All of the isolated compounds were examined for steroid 5 alpha-reductase inhibitory activity. Cyclospongiaquinone 1 (5) showed a strong activity in the same range as that of standard finasteride.

Harvard-Zitierstil: Jiso, A., Kittiwisut, S., Chantakul, R., Yuenyongsawad, S., Putchakarn, S., Schäberle, T., et al. (2020) Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper, Journal of Natural Products, 83(2), pp. 532-536. https://doi.org/10.1021/acs.jnatprod.9b00886

APA-Zitierstil: Jiso, A., Kittiwisut, S., Chantakul, R., Yuenyongsawad, S., Putchakarn, S., Schäberle, T., Temkitthaworn, P., Ingkaninan, K., Chaithirayanon, K., & Plubrukarn, A. (2020). Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper. Journal of Natural Products. 83(2), 532-536. https://doi.org/10.1021/acs.jnatprod.9b00886