Journal article

Publication year: 2020

Pages: 1310-

Journal: Biomolecules

Volume number: 10

Issue number: 9

eISSN: 2218-273X

Open access status: Gold

DOI Link: https://doi.org/10.3390/biom10091310

Publisher: MDPI

Abstract: 
Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli. However, how signaling pathways regulate the assembly of RBPs with mRNAs remains largely unknown. Here, we summarize observations showing that the formation and composition of messenger ribonucleoprotein particles (mRNPs) is dynamically remodeled in space and time by specific signaling cascades and the resulting post-translational modifications. The integration of signaling events with gene expression is key to the rapid adaptation of cells to environmental changes and stress. Only a combined approach analyzing the signal transduction pathways and the changes in post-transcriptional gene expression they cause will unravel the mechanisms coordinating these important cellular processes.

Harvard Citation style: Zarnack, K., Balasubramanian, S., Gantier, M., Kunetsky, V., Kracht, M., Schmitz, M., et al. (2020) Dynamic mRNP Remodeling in Response to Internal and External Stimuli, Biomolecules, 10(9), Article 1310. p. 1310. https://doi.org/10.3390/biom10091310

APA Citation style: Zarnack, K., Balasubramanian, S., Gantier, M., Kunetsky, V., Kracht, M., Schmitz, M., & Sträßer, K. (2020). Dynamic mRNP Remodeling in Response to Internal and External Stimuli. Biomolecules. 10(9), Article 1310, 1310. https://doi.org/10.3390/biom10091310