Journalartikel

Jahr der Veröffentlichung: 2019

Seiten: 1800533-

Zeitschrift: Macromolecular Rapid Communications

Bandnummer: 40

Heftnummer: 6

ISSN: 1022-1336

eISSN: 1521-3927

Open Access Status: Green

DOI Link: https://doi.org/10.1002/marc.201800533

Verlag: Wiley

Abstract: 
Here, the combinatorial synthesis of molecule arrays via a laser-assisted process is reported. Laser-transferred polymer nanolayers with embedded monomers, activators, or bases can be reliably stacked on top of each other, spot-by-spot, to synthesize molecule arrays. These various chemicals in the nanometer-thin layers are mixed by heat or solvent vapor, inducing coupling reactions. As an example, peptoid arrays with a density of 10 000 spots per cm(2) with the sub-monomer or monomer method are generated. Moreover, successful reactions spot-by-spot are verified by laser-transferring MALDI-matrix (Matrix-assisted laser desorption/ionization) followed by MALDI mass spectrometry imaging.

Harvard-Zitierstil: Mattes, D., Streit, B., Bhandari, D., Greifenstein, J., Foertsch, T., Münch, S., et al. (2019) Combinatorial Synthesis of Peptoid Arrays via Laser-Based Stacking of Multiple Polymer Nanolayers, Macromolecular Rapid Communications, 40(6), Article 1800533. p. 1800533. https://doi.org/10.1002/marc.201800533

APA-Zitierstil: Mattes, D., Streit, B., Bhandari, D., Greifenstein, J., Foertsch, T., Münch, S., Ridder, B., v. Bojničić-Kninski, C., Nesterov-Mueller, A., Spengler, B., Schepers, U., Bräse, S., Loeffler, F., & Breitling, F. (2019). Combinatorial Synthesis of Peptoid Arrays via Laser-Based Stacking of Multiple Polymer Nanolayers. Macromolecular Rapid Communications. 40(6), Article 1800533, 1800533. https://doi.org/10.1002/marc.201800533