Journal article

Publication year: 2023

Journal: EFSA Journal

Volume number: 21

Issue number: 2

DOI Link: https://doi.org/10.2903/j.efsa.2023.7834

Publisher: Wiley

Abstract: 

The food enzyme 1,4-α-glucan branching enzyme ((1–4)-α-d-glucan:(1–4)-α-d-glucan 6-α-d-[(1–4)-α-d-glucano]-transferase; EC 2.4.1.18) is produced with the non-genetically modified Geobacillus thermodenitrificans strain TRBE14 by Nagase (Europa) GmbH. The production strain has been shown to qualify for the qualified presumption of safety (QPS) approach. The food enzyme is intended to be used in cereal-based processes, baking processes as well as meat and fish processing. Dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be up to 0.29 mg TOS/kg body weight (bw) per day in European populations. Toxicological studies were not considered necessary given the QPS status of the production strain and the nature of the manufacturing process. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel noted that the food enzyme contains lysozyme, a known allergen. Therefore, allergenicity cannot be excluded. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.

Harvard Citation style: EFSA CEP Panel, Lambré, C., Baviera, J., Bolognesi, C., Cocconcelli, P., Crebelli, R., et al. (2023) Safety evaluation of the food enzyme 1,4-α-glucan branching enzyme from the non-genetically modified Geobacillus thermodenitrificans strain TRBE14, EFSA Journal, 21(2), Article e07834. https://doi.org/10.2903/j.efsa.2023.7834

APA Citation style: EFSA CEP Panel, Lambré, C., Baviera, J., Bolognesi, C., Cocconcelli, P., Crebelli, R., Gott, D., Grob, K., Lampi, E., Mengelers, M., Mortensen, A., Rivière, G., Steffensen, I., Tlustos, C., Van Loveren, H., Vernis, L., Zorn, H., Glandorf, B., Herman, L., ...Chesson, A. (2023). Safety evaluation of the food enzyme 1,4-α-glucan branching enzyme from the non-genetically modified Geobacillus thermodenitrificans strain TRBE14. EFSA Journal. 21(2), Article e07834. https://doi.org/10.2903/j.efsa.2023.7834