N,N-Dimethylacetamide – Addendum for re-evaluation of the BAT value. Assessment Values in Biological Material – Translation of the German version from 2020 - Research portal of Justus Liebig University Giessen:

Journal article

N,N-Dimethylacetamide – Addendum for re-evaluation of the BAT value. Assessment Values in Biological Material – Translation of the German version from 2020

Authors list: Walter, D; Drexler, H; Hartwig, A; MAK Commission

Publication year: 2020

Journal: The MAK collection for occupational health and safety : Begründungen und Methoden : documentation and methods

Volume number: 5

Issue number: 3

DOI Link: https://doi.org/10.34865/bb12719e5_3ad

Publisher: ZB MED - Informationszentrum Lebenswissenschaften

Abstract:

In 2019, the German Commission for the Investigation of Health Hazards of
Chemical Compounds in the Work Area has re-evaluated the BAT value of
N,N-dimethylacetamide [127-19‑5], following the re-evaluation of the MAK value. The major routes of uptake of N,N-dimethylacetamide in the workplace are inhalation and nearly 30% dermal absorption. Several studies indicated a non-linear correlation between occupational exposure and urinary excretion of N‑methylacetamide. An equation for the correlation between occupational exposure to N,N-dimethylacetamide in air and urinary excretion of N‑methylacetamide was reported, which is in line with the results of field and human exposure studies. The equation does not consider the additional dermal uptake of liquid N,N-dimethylacetamide. In correlation to the MAK value of 5 mg N,N-dimethylacetamide/m3, a BAT value of 25 mg N‑methylacetamide plus N‑hydroxymethyl-N-methylacetamide/l urine was established. Sampling time is at the end of exposure or end of shift. Sampling time for long-term exposures is at the end of the shift after several shifts

Citation Styles

Harvard Citation style: Walter, D., Drexler, H., Hartwig, A. and MAK Commission (2020) N,N-Dimethylacetamide – Addendum for re-evaluation of the BAT value. Assessment Values in Biological Material – Translation of the German version from 2020 , The MAK collection for occupational health and safety : Begründungen und Methoden : documentation and methods, 5(3), Article Doc058. https://doi.org/10.34865/bb12719e5_3ad

APA Citation style: Walter, D., Drexler, H., Hartwig, A., & MAK Commission (2020). N,N-Dimethylacetamide – Addendum for re-evaluation of the BAT value. Assessment Values in Biological Material – Translation of the German version from 2020 . The MAK collection for occupational health and safety : Begründungen und Methoden : documentation and methods. 5(3), Article Doc058. https://doi.org/10.34865/bb12719e5_3ad