Journalartikel

Safety evaluation of the food enzyme AMP deaminase from the non-genetically modified Streptomyces murinus strain AE-DNTS


AutorenlisteEFSA CEP Panel; Lambré, C; Barat Baviera, JM; Bolognesi, C; Cocconcelli, PS; Crebelli, R; Gott, DM; Grob, K; Lampi, E; Mengelers, M; Mortensen, A; Rivière, G; Steffensen, IL; Tlustos, C; Van Loveren, H; Vernis, L; Zorn, H; Roos, Y; Andryszkiewicz, M; Liu, Y; Lunardi, S; Nielsen, E; Nørby, K; Chesson, A

Jahr der Veröffentlichung2023

ZeitschriftEFSA Journal

Bandnummer21

Heftnummer3

ISSN1831-4732

DOI Linkhttps://doi.org/10.2903/j.efsa.2023.7915

VerlagWiley


Abstract

The food enzyme AMP deaminase (AMP aminohydrolase; EC 3.5.4.6) is produced with the non-genetically modified Streptomyces murinus strain AE-DNTS by Amano Enzyme Inc. The food enzyme is free from viable cells. It is intended to be used in yeast processing and the production of mushroom extracts. Dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be up to 0.0004 mg TOS/kg body weight (bw) per day in European populations. The food enzyme batches, including the batch used in the toxicological studies, were not fully characterised. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood is low. In the absence of adequate toxicological data, the Panel could not conclude on the safety of the food enzyme AMP deaminase from the non-genetically modified Streptomyces murinus strain AE-DNTS.




Autoren/Herausgeber




Zitierstile

Harvard-ZitierstilEFSA CEP Panel, Lambré, C., Barat Baviera, J., Bolognesi, C., Cocconcelli, P., Crebelli, R., et al. (2023) Safety evaluation of the food enzyme AMP deaminase from the non-genetically modified Streptomyces murinus strain AE-DNTS, EFSA Journal, 21(3), Article e07915. https://doi.org/10.2903/j.efsa.2023.7915

APA-ZitierstilEFSA CEP Panel, Lambré, C., Barat Baviera, J., Bolognesi, C., Cocconcelli, P., Crebelli, R., Gott, D., Grob, K., Lampi, E., Mengelers, M., Mortensen, A., Rivière, G., Steffensen, I., Tlustos, C., Van Loveren, H., Vernis, L., Zorn, H., Roos, Y., Andryszkiewicz, M., ...Chesson, A. (2023). Safety evaluation of the food enzyme AMP deaminase from the non-genetically modified Streptomyces murinus strain AE-DNTS. EFSA Journal. 21(3), Article e07915. https://doi.org/10.2903/j.efsa.2023.7915


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