Journal article
Authors list: Dilberger, B; Weppler, S; Eckert, GP
Publication year: 2021
Journal: Mechanisms of Ageing and Development
Volume number: 198
ISSN: 0047-6374
eISSN: 1872-6216
DOI Link: https://doi.org/10.1016/j.mad.2021.111518
Publisher: Elsevier
Introduction: Methods: Results: Conclusion:
Abstract:
Aging represents a major risk factors for metabolic diseases, such as diabetes, obesity, or neurodegeneration. Polyphenols and their metabolites, especially simple phenolic acids, gained growing attention as a preventive strategy against age-related, non-communicable diseases, due to their hormetic potential. Using Caenorhabditis elegans (C. elegans) we investigate the effect of protocatechuic, gallic, and vanillic acid on mitochondrial function, health parameters, and the induction of potential hormetic pathways.
Lifespan, heat-stress resistance and chemotaxis of C. elegans strain P X 627, a specific model for aging, were assessed in 2-day and 10-day old nematodes. Mitochondrial membrane potential (Delta Psi m) and ATP generation were measured. mRNA expression levels of longevity and energy metabolism-related genes were determined using qRT-PCR.
All phenolic acids were able to significantly increase the nematodes lifespan, heat-stress resistance and chemotaxis at micromolar concentrations. While Delta Psi m was only affected by age, vanillic acid (VA) significantly decreased ATP concentrations in aged nematodes. Longevity pathways, were activated by all phenolic acids, while VA also induced glycolytic activity and response to cold.
While life- and health span parameters are positively affected by the investigated phenolic acids, the concentrations applied were unable to affect mitochondrial performance. Therefore we suggest a hormetic mode of action, especially by activation of the sirtuin-pathway.
Citation Styles
Harvard Citation style: Dilberger, B., Weppler, S. and Eckert, G. (2021) Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans, Mechanisms of Ageing and Development, 198, Article 111518. https://doi.org/10.1016/j.mad.2021.111518
APA Citation style: Dilberger, B., Weppler, S., & Eckert, G. (2021). Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans. Mechanisms of Ageing and Development. 198, Article 111518. https://doi.org/10.1016/j.mad.2021.111518
