Journal article

Publication year: 2023

Journal: International Journal of Molecular Sciences

Volume number: 24

Issue number: 12

ISSN: 1661-6596

eISSN: 1422-0067

Open access status: Gold

DOI Link: https://doi.org/10.3390/ijms241210029

Publisher: MDPI

Abstract: 
Alzheimer's disease (AD) is characterized by excessive formation of beta-amyloid peptides (A & beta;), mitochondrial dysfunction, enhanced production of reactive oxygen species (ROS), and altered glycolysis. Since the disease is currently not curable, preventive and supportive approaches are in the focus of science. Based on studies of promising single substances, the present study used a mixture (cocktail, SC) of compounds consisting of hesperetin (HstP), magnesium-orotate (MgOr), and folic acid (Fol), as well as the combination (KCC) of caffeine (Cof), kahweol (KW) and cafestol (CF). For all compounds, we showed positive results in SH-SY5Y-APP(695) cells-a model of early AD. Thus, SH-SY5Y-APP(695) cells were incubated with SC and the activity of the mitochondrial respiration chain complexes were measured, as well as levels of ATP, A & beta;, ROS, lactate and pyruvate. Incubation of SH-SY5Y-APP(695) cells with SC significantly increased the endogenous respiration of mitochondria and ATP levels, while A & beta;(1-40) levels were significantly decreased. Incubation with SC showed no significant effects on oxidative stress and glycolysis. In summary, this combination of compounds with proven effects on mitochondrial parameters has the potential to improve mitochondrial dysfunction in a cellular model of AD.

Harvard Citation style: Babylon, L., Meißner, J. and Eckert, G. (2023) Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease, International Journal of Molecular Sciences, 24(12), Article 10029. https://doi.org/10.3390/ijms241210029

APA Citation style: Babylon, L., Meißner, J., & Eckert, G. (2023). Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease. International Journal of Molecular Sciences. 24(12), Article 10029. https://doi.org/10.3390/ijms241210029