Journal article

Publication year: 2022

Pages: 13168-13177

Journal: The Journal of Organic Chemistry

Volume number: 87

Issue number: 19

ISSN: 0022-3263

eISSN: 1520-6904

DOI Link: https://doi.org/10.1021/acs.joc.2c01633

Publisher: American Chemical Society

Abstract: 
We present an experimental and computational study to investigate noncovalent interactions between silyl groups that are often employed as "innocent" protecting groups. We chose an extended cyclooctatetraene (COT)-based molecular balance comprising unfolded (1,4-disubstituted) and folded (1,6-disubstituted) valance bond isomers that typically display remote and close silyl group contacts, respectively. The thermodynamic equilibria were determined using nuclear magnetic resonance measurements. Additionally, we utilized Boltzmann weighted symmetry adapted perturbation theory (SAPT) at the sSAPT0/aug-cc-pVDZ level of theory to dissect and quantify noncovalent interactions. Apart from the extremely bulky tris(trimethylsilyl)silyl "supersilyl" group, there is a preference for the folded 1,6 COT valence isomer, with London dispersion interactions being the main stabilizing factor. This makes silyl groups excellent dispersion energy donors, a finding that needs to be taken into account in synthesis planning.

Harvard Citation style: Rummel, L., König, H., Hausmann, H. and Schreiner, P. (2022) Silyl Groups Are Strong Dispersion Energy Donors, The Journal of Organic Chemistry, 87(19), pp. 13168-13177. https://doi.org/10.1021/acs.joc.2c01633

APA Citation style: Rummel, L., König, H., Hausmann, H., & Schreiner, P. (2022). Silyl Groups Are Strong Dispersion Energy Donors. The Journal of Organic Chemistry. 87(19), 13168-13177. https://doi.org/10.1021/acs.joc.2c01633