Journal article

Publication year: 2004

Pages: 300-306

Journal: Biochemical and Biophysical Research Communications

Volume number: 316

Issue number: 2

ISSN: 0006-291X

eISSN: 1090-2104

DOI Link: https://doi.org/10.1016/j.bbrc.2004.02.048

Publisher: Elsevier

Abstract: 
In this study, a novel sodium-dependent organic anion transporter (Soat) was identified. Soat is expressed in rat brain, heart, kidney, lung, muscle, spleen, testis, adrenal gland, small intestine, and colon. The Soat protein consists of 370 amino acids and shows 42%, and 31% overall amino acid sequence identity to the ileal sodium-dependent bile acid transporter (Isbt) and the Na+/taurocholate cotransporting polypeptide (Ntcp), respectively. Soat is predicted to have nine transmembrane domains, with an N-terminus outside the cell and an intracellular C-terminus. The Soat gene is localized on chromosome 14 and is coded by six exons mapped in region 14p22. When expressed in Xenopus laevis oocytes, Soat shows transport function for estrone-3-sulfate (K-m = 31 muM, V-max = 5557 fmol/oocyte/30 min) and dehydroepiandrosterone sulfate (K-m = 30 muM, V-max = 5682 fmol/oocyte/30 min). Soat does not transport taurocholate, estradiol-17beta-glucuronide, nor ouabain. Published by Elsevier Inc.

Harvard Citation style: Geyer, J., Godoy, J. and Petzinger, E. (2004) Identification of a sodium-dependent organic anion transporter from rat adrenal gland, Biochemical and Biophysical Research Communications, 316(2), pp. 300-306. https://doi.org/10.1016/j.bbrc.2004.02.048

APA Citation style: Geyer, J., Godoy, J., & Petzinger, E. (2004). Identification of a sodium-dependent organic anion transporter from rat adrenal gland. Biochemical and Biophysical Research Communications. 316(2), 300-306. https://doi.org/10.1016/j.bbrc.2004.02.048