Journal article

Publication year: 2023

Journal: International Journal of Molecular Sciences

Volume number: 24

Issue number: 12

ISSN: 1661-6596

eISSN: 1422-0067

Open access status: Gold

DOI Link: https://doi.org/10.3390/ijms24129926

Publisher: MDPI

Abstract: 

The sodium-dependent organic anion transporter (SOAT, gene symbol SLC10A6) specifically transports 3´- and 17´-monosulfated steroid hormones, such as estrone sulfate and dehydroepiandrosterone sulfate, into specific target cells. These biologically inactive sulfo-conjugated steroids occur in high concentrations in the blood circulation and serve as precursors for the intracrine formation of active estrogens and androgens that contribute to the overall regulation of steroids in many peripheral tissues. Although SOAT expression has been detected in several hormone-responsive peripheral tissues, its quantitative contribution to steroid sulfate uptake in different organs is still not completely clear. Given this fact, the present review provides a comprehensive overview of the current knowledge about the SOAT by summarizing all experimental findings obtained since its first cloning in 2004 and by processing SOAT/SLC10A6-related data from genome-wide protein and mRNA expression databases. In conclusion, despite a significantly increased understanding of the function and physiological significance of the SOAT over the past 20 years, further studies are needed to finally establish it as a potential drug target for endocrine-based therapy of steroid-responsive diseases such as hormone-dependent breast cancer.

Harvard Citation style: Wannowius, M., Karakus, E., Aktürk, Z., Breuer, J. and Geyer, J. (2023) Role of the Sodium-Dependent Organic Anion Transporter (SOAT/SLC10A6) in Physiology and Pathophysiology, International Journal of Molecular Sciences, 24(12), Article 9926. https://doi.org/10.3390/ijms24129926

APA Citation style: Wannowius, M., Karakus, E., Aktürk, Z., Breuer, J., & Geyer, J. (2023). Role of the Sodium-Dependent Organic Anion Transporter (SOAT/SLC10A6) in Physiology and Pathophysiology. International Journal of Molecular Sciences. 24(12), Article 9926. https://doi.org/10.3390/ijms24129926