Journal article

Publication year: 2013

Pages: 5300-5304

Journal: Journal of Virology

Volume number: 87

Issue number: 9

ISSN: 0022-538X

DOI Link: https://doi.org/10.1128/JVI.03496-12

Publisher: American Society for Microbiology

Abstract: 

Infections with human coronavirus EMC (HCoV-EMC) are associated with severe pneumonia. We demonstrate that HCoV-EMC resembles severe acute respiratory syndrome coronavirus (SARS-CoV) in productively infecting primary and continuous cells of the human airways and in preventing the induction of interferon regulatory factor 3 (IRF-3)-mediated antiviral alpha/beta interferon (IFN-α/β) responses. However, HCoV-EMC was markedly more sensitive to the antiviral state established by ectopic IFN. Thus, HCoV-EMC can utilize a broad range of human cell substrates and suppress IFN induction, but it does not reach the IFN resistance of SARS-CoV.

Harvard Citation style: Zielecki, F., Weber, M., Eickmann, M., Spiegelberg, L., Zaki, A., Matrosovich, M., et al. (2013) Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus, Journal of Virology, 87(9), pp. 5300-5304. https://doi.org/10.1128/JVI.03496-12

APA Citation style: Zielecki, F., Weber, M., Eickmann, M., Spiegelberg, L., Zaki, A., Matrosovich, M., Becker, S., & Weber, F. (2013). Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus. Journal of Virology. 87(9), 5300-5304. https://doi.org/10.1128/JVI.03496-12