Journalartikel

Jahr der Veröffentlichung: 2013

Seiten: 12489-12495

Zeitschrift: Journal of Virology

Bandnummer: 87

Heftnummer: 22

ISSN: 0022-538X

eISSN: 1098-5514

DOI Link: https://doi.org/10.1128/JVI.01845-13

Verlag: American Society for Microbiology

Abstract: 

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA.

Harvard-Zitierstil: Niemeyer, D., Zillinger, T., Muth, D., Zielecki, F., Horvath, G., Suliman, T., et al. (2013) Middle East Respiratory Syndrome Coronavirus Accessory, Journal of Virology, 87(22), pp. 12489-12495. https://doi.org/10.1128/JVI.01845-13

APA-Zitierstil: Niemeyer, D., Zillinger, T., Muth, D., Zielecki, F., Horvath, G., Suliman, T., Barchet, W., Weber, F., Drosten, C., & Müller, M. (2013). Middle East Respiratory Syndrome Coronavirus Accessory. Journal of Virology. 87(22), 12489-12495. https://doi.org/10.1128/JVI.01845-13